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Peptides work best as part of a comprehensive approach

doi: 10.1038/s41586-020-2121-3

H., Bell, D

Prx3 homodimer has a redox-sensitive cysteine that upon reaction with H 2 O 2 is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by thioredoxin reductase 2 (TrxRD2

Mitochondrial impairment and dysregulation of mitochondrial proteins are present in postmortem brain and spinal cord tissues of ALS patients and SOD1 G93A mice (Carr et al., 2003

Its degradation is facilitated by a group of prolyl hydroxylase enzymes (PHDs) that are dependent on oxygen and iron [23]