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Kinetic experiments in the presence of -butyrobetaine revealed a high activity of 2.1 0.2 mol min 1 mg 1 which is in agreement with a recently published structural investigation (Quareshy et al., 2020)

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Am J Gastroenterol 2000;95:2029-2034

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Methylphenidate might be considered as a first choice since it is the only psychostimulant that has shown a superior effect over placebo in three RCTs [34,35,39] while all RCTs on modafinil have been negative [40,41,42]

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