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Trends Genet 36 , 702717 (2020)

Nian Liu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Iron limitation inhibits iron-sulfur cluster-dependent protein lipoylation, causing the loss and inactivation of the LAT1 subunit of pyruvate dehydrogenase, thereby promoting glucose flow to the pentose phosphate pathway to increase NADPH production, and inducing non-PDH pathways such as the pyruvate bypass and fatty acid oxidation to synthesize acetyl coenzyme A, thereby maintaining survival in an iron-limited environment (Garg et al., 2025)