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One of them is that some of the data were collected retrospectively, which entails a risk of bias

Peripheral blood count abnormalities among patients with hepatitis C in the United States

In this context, cells reroute glutamine into the reductive carboxylation pathway: NADP + -dependent isocitrate dehydrogenase runs in reverse to convert -ketoglutarate (from glutamine) into citrate, which is cleaved to acetyl-CoA for fatty acid synthesis 98

Its not the FDAs job, he insisted, to dictate what physicians can prescribe or what patients can take

The absence of safety data in these populations should inform clinical decision-making and prescribing practices