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doi: 10.1016/S0165-5728(00)00422-7 77 SaundersJAHEstesKAKosloskiLMAllenHEDempseyKMTorres-RussottoDRet al

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R.ProzorovskiT.GellertM.HauptmannG.et al

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This insight, which implied that a substance could be harmful at a high dose but beneficial or benign at a low one, directly prefigured the biphasic dose-responses central to hormesis and laid the groundwork for modern toxicology

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