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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis

Kramer, E

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In a murine model, riboflavin supplementation increases glucose uptake and ameliorates oxidative stress

Prepared formulations should be kept refrigerated and used within their stability window

Ferioun et al., 2023a, b), the roles attributed to this amino-acid are numerous, the most recorded are in relation with osmo-regulation, scavenging free radicals, membranes steadiness (Marciska et al., 2013)