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B-12 deficiency is more common than most people realize, affecting around 6% of Americans younger than 60 and around 20% of those older than 60, though the exact numbers vary

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Following brain injury, results have suggested an increase in expression of DAG and protein kinase C (PKC), key drivers of secondary calcium signaling, which can directly interact with ROCs and VGCCs to further amplify calcium influx into the intracellular space within neurons

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