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Furthermore, flavokavains A and B were shown to have immunomodulatory functions, such as the stimulation of splenocyte proliferation and the secretion of IL-2 and TNF- in harvested splenocytes, as well as an increase in the subsets of T cell populations in BALB/c mice, with flavokavain B being more potent than flavokavain A (30 g/mL) [59]

These patients must also have either pathogenic variant(s) in a SCID-associated gene or reduced T-cell proliferation to certain mitogens

The majority of cytokines and CXC chemokines are highly expressed during PCa and aid in the pathogenesis of PCa by causing inflammation, but their molecular bases have not yet been fully explored

Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity