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Response: We appreciate this explanation and will consider these comments as we move forward with implementation to ensure that the benefit meets the needs of beneficiaries impacted by primary immunodeficiency diseases

The mechanism appears to involve stimulation of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) activity, leading to accelerated triglyceride hydrolysis and increased free fatty acid release

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The researchers evaluated the patient-reported outcomes of over 150 different real-world treatments to determine which interventions provided the most significant relief