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Description
Mechanistically, L-DON and JHU-083 suppressed tumor glutamine metabolism by inhibiting all the glutamine-utilizing enzymes, and simultaneously suppressed tumor glycolysis by activating AMP Kinase (AMPK) and inhibiting the expression of c-MYC [114, 115]

In all cases, if there are any reasonable permitted alternatives to GCs then the physician should document why the GC was the most appropriate treatment

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[DOI] [PubMed] [Google Scholar] 15.Winterbourn C.C

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