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In the short term, cortisol is useful for responding to danger by fighting or flying

LiYDLuoYJChenZKQuintanillaLCherasseYZhangLet alHypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior
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However, a serious concern in targeting Wnt/-catenin pathway is the effect this may have in physiological cell renewal: additional studies are needed to assess side effects of in vivo use of the Wnt/-catenin antagonists in endometriosis

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