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Oxidative stress can be induced in two main ways: directly increasing ROS levels or impairing antioxidant defense systems

The AST level in serum, as shown in Table 3 dropped significantly in rat exposed to 2% and 5% green tea ( P 0.05)

Another consequence of UPR is the activation of SREBP-1c pathways, which results in the maintenance of liver fat accumulation and a further exacerbation of ER stress and UPR ( 3 CHM used in treatment for NAFLD NAFLD is a complex metabolic disorder that often co-occurs with other metabolic conditions such as dyslipidemia, hypertension, and diabetes mellitus (Zhao et al., 2018)

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The authors speculated that excessive mitophagy inhibits the antioxidant capacity of Fas in NDP52 overexpressed cells, indicating that NDP52 aggravated neomycin-induced ototoxicity

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