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Hat makers often ended up with mercury poisoning symptoms that caused memory loss and personality changes

The levels of 4-HNE are remarkably elevated under conditions of oxidative stress and it is considered as one of the reliable biomarker of oxidative stress 64

They suggest inflammation/oxidative stress induced basal ganglia damage may be causing fatigue in both groups

JCI Insight 7 , e155827 (2022)

Journal of Neurochemistry, 97 (2), 303309

3 Blocking proteasomal degradation leads to the accumulation of intracellular proteins and subsequent cellular stress, 4 which in turn inhibits proliferation and induces apoptosis of myeloma cells