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Apo E can mediate the binding of lipoproteins to negatively charged GAGs chains of arterial PGs and the co-localization of Apo E and biglycan in lesions has been testified 16

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In that study, HCV-ITP was diagnosed by the following criteria: the diagnosis of HCV either before or concurrent with documentation of TCP, TCP out of proportion to the severity of the liver disease, a positive anti-Plt antibody test, and a response to agents known to be effective in the treatment of ITP (e.g., corticosteroids, cyclophosphamide) in patients who required therapy (six of the seven patients)

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