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Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project

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Importantly, in these experimental models, pre-hypoxic treatment with sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) or oxfenicine, both inhibitors of CPT I, prevents membrane and cytosolic LCAC accumulation in early ischaemia and the genesis of electrophysiological derangements (Yamada et al., 1994)

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At the 1.5 g /day dose of GPLC, improvements in PP and MP were observed compared to baseline values