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Description
Linolenic acid is desaturated to 18:4n-3 (6,9,12,15-C18:4) by 6-desaturase, chain-elongated to 20:4n-3 (8,11,14,17-C20:4), and subsequently converted to eicosapentaenoic acid (20:5n-3
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Aluigi MG, De Flora S, D'Agostini F, Albini A, Fassina G
The NOAEL for these effects was 125 mg -tocopheryl acetate/kg body weight (Abdo et al., 1986)

By assessing the robustness, potential vulnerabilities and areas for improvement can be identified, leading to a more reliable and effective combination