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N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research

Bacterial mutants that induced significantly higher aversion than BW25113_WT were chosen for subsequent studies
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Multi-omic analysis of 292 paired datasets demonstrated a strong positive correlation between fecal gbu genes, particularly gbuB , and TMAO production
It is widely known that mitochondrial dysfunction (high ROS production, apoptotic cells, decreased m, and low cellular ATP levels) boosts the pathogenesis of KOA because it involves lipid homeostasis and cytokine release and promotes cell apoptosis [14, 15]