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10.1016/j.eclinm.2022.101821 [DOI] [PMC free article] [PubMed] [Google Scholar] Mori JO, Keegan J, Flynn RL, Heaphy CM (2024) Alternative lengthening of telomeres: mechanism and the pathogenesis of cancer

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inject PRP around the nerve to separate adhesions and deliver growth factors Aftercare: brief rest followed by gentle hip mobility exercises and physical therapy Evidence Summary Case reports describe successful PRP hydrodissection of the LFCN with significant symptom relief Animal models demonstrate accelerated axonal growth and increased myelin thickness with PRP application Systematic reviews highlight PRPs safety profile and call for controlled trials in entrapment neuropathies Advantages & Considerations Advantages Autologous and low risk of allergy Minimally invasive outpatient procedure Combines mechanical hydrodissection with regenerative biology Considerations Variability in PRP formulations (platelet concentration, leukocyte content) Cost and insurance coverage may vary Need for high-quality, long-term clinical trials Future Directions Standardize PRP preparation protocols (platelet counts, leukocyte levels) Conduct comparative trials versus corticosteroids or dextrose prolotherapy Evaluate long-term outcomes through imaging and electrophysiology Take-Home Messages Meralgia paresthetica is a sensory neuropathy caused by compression of the LFCN, leading to outer-thigh burning, tingling, or numbness Most cases improve with lifestyle changes, medications, and nerve blocks PRP hydrodissection offers a novel regenerative approach for refractory cases Rigorous clinical trials are needed before PRP becomes a standard treatment

Subsequent studies confirmed its predominant expression in the hypothalamus under physiological conditions

It actively binds to growth factor receptors including VEGFR-2 and modulates nitric oxide pathways that control vasodilation and angiogenesis

Mitochondrial ROS drive sudden cardiac death and chronic proteome remodeling in heart failure