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The main purpose of this study is to provide a comprehensive overview of the toxicity of PHMG

Aging Cell 21, e13725

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Cycle Guidelines Common Cagrilintide Research Cycle Lengths Approach Short cycle Duration 16 weeks Review Point Week 16 Notes Reaches maintenance just as titration completes Approach Standard cycle Duration 26-32 weeks Review Point Week 26 / 32 Notes Matches Phase 2 trial durations Approach Long cycle Duration 68 weeks Review Point Week 68 Notes Matches REDEFINE 1 and REDEFINE 2 endpoints Cycle length is a research planning choice, not a treatment recommendation

In PRISMS-4, the PRISMS-2 placebo patients were re-randomized to either 22 or 44 mcg