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Furthermore, a large number of genetic variants have been described in the UGT genes that are due to mutations in both the coding and regulatory regions of the genes[4853]
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Olaparib is a compound that effectively inhibits PARP1 and PARP2, binding to the catalytic domain and preventing the transfer of ADP-ribose units from NAD + to target proteins, thus lowering NAD + consumption 160,161
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