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When AMPK is phosphorylated, it shifts cells toward energy conservation by inhibiting mTORC1 and stimulating fat breakdown and glucose uptake (86)

TafazoliS.Mechanisms of drug-induced oxidative stress in the hepatocyte inflammation model,Doctor of Philosophy, Department of Pharmaceutical Sciences, University of Toronto,2008 27

In our study, Nrf2 WT and KO thyroid organoids differentiated with TSH instead of cAMP showed the same down-regulation in Tg mRNA expression, suggesting that the effect is mainly driven by the lack of Nrf2 biding to the ARE sequence of Tg promoter

CDDO-Me treatment increased the expression of NRF2 target genes (Fig

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