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The other challenge in the discovery of AMPK activators is the multiple mechanisms of AMPK activators in multiple tissues and their differential effects on biochemical pathways in those tissues (i.e., liver, muscle, and adipose)

The blood-brain barrier, oxidative stress, and insulin resistance

W.CrawfordD

Adv Exp Med Biol 1999;466:327-37 83 -Carpenter KH ea

& Delgoffe, G
