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447,448,449,450 VGCCs, present in the presynaptic terminal, are responsible for neurotransmitter release and the propagation of pain signals to second-order neurons

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Whether or not objective criteria are eventually useful in diagnosing RLS depends on how well-understood the patient's symptoms are and how forthcoming the patient is with the researcher, as the sensations are subjective to the patient

The reason behind this is that even simple peri-lesional injections implicate trauma, be it ever so mild, and as trauma is beyond any doubt the trigger for the onset of PD, it should be avoided as much as possible [7,8,9]