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The above processes contribute to the inactivation of key pathways of cholesterol synthesis and reduce cholesterol biosynthesis

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It is thought that inhibition of the RAF kinase signaling pathway may have an additional effect on keratinocyte differentiation and proliferation.30 It is interesting that other multikinase inhibitors that share the same mechanism of action have not been associated with any increase in the risk of malignant and premalignant skin lesions

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Firstly, this study was conducted using a relatively small number of participants