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CagriSema is a fixed-ratio combination of two separate compounds one (semaglutide) targeting the GLP-1 receptor and one (cagrilintide) targeting amylin receptors

doi: 10.3390/ijms24043735

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The results clearly demonstrate the ability of HGF and Dihexa to work synergistically to activate c Met

However, after adjusting for multiple comparison (HolmSidak method), the relationship verged on significance (adjusted p = 0.08)

This is appropriate when the same vial of reconstituted cagrilintide will be sampled over days or weeks