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It is worth noting that microecological dysregulation associated with low vitamin D status is not limited to the oral cavity or intestinal level, but is also closely related to an increased risk of cardiometabolic diseases such as metabolic syndrome (MetSyn), obesity, and type 2 diabetes mellitus (T2DM) (Sukik et al., 2023)

PMID 14555227

Human studies are few and are largely restricted to small pilot trials with short follow-up periods, limited statistical power, and non-standardized outcome measures

Human hepatocellular carcinoma: protection by melatonin

Its this unique stability that opens the door to oral use, but it also creates the dosage dilemma were here to solve

Oral supplements may not also be best for those with acute B12 deficiency, as theres no way to tell how much is getting absorbed by the body