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Most recently, a randomized, placebo-controlled trial in 40 obese men (ages, 40-70 years) found that daily supplementation with nicotinamide riboside (2,000 mg/day divided into two daily dosages) for 12 weeks was associated with reports of only minor side effects, including excessive sweating, pruritus, and mild gastrointestinal symptoms like bloating (139)

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Helps regulate mood, easing symptoms of stress and anxiety

Regulatory status (US) FDA-approved prescription drugs These compounds work through different mechanisms and are not interchangeable