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doi: 10.1023/A:1007156732662

Future studies incorporating short-term intervention protocols, pair-fed or weight-matched control groups, and adipose tissuespecific receptor manipulation will be essential to further delineate the relative contributions of direct receptor-mediated actions versus secondary effects of adiposity reduction
The potential of targeting mitochondrial dysfunction as a therapeutic strategy has been underscored by studies on Metformin, an AMPK agonist

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Sex steroid axes in determining male predominance in hepatocellular carcinoma