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Targeting or depleting cit C presents a novel therapeutic approach, including anti-FITC CAR-T cells directed against FITC-labeled citrullinated peptides to selectively target self-reactive B cells, though this remains preclinical (44)
Some studies have reported that antioxidants can influence gene expression through epigenetic modifications
GC18256 PF-06281355 PF-06281355 PF-06281355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases

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doi: 10.1002/mnfr.201801230