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With the comprehensive application of ferroptosis molecular probes, gene editing tools, and artificial intelligence prediction models, treatment strategies will gradually shift from generalized inhibition to spatiotemporal precise intervention. Statements Author contributions CX: Writing original draft, Conceptualization, Methodology, Writing review & editing

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was supported by the National Natural Science Foundation of China (31971364 and 32370148), the National Key R&D Program of China (2022YFC3400205) and the Shanghai Jiao Tong University Scientific and Technological Innovation Funds Key forward-looking layout fund from Shanghai Jiao Tong University (number AF4150049)

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In addition, TAT peptides can transport goods through the cell membrane more efficiently than NLS, thereby promoting the delivery of nanoparticles to the nucleus with higher efficiency