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The biology is doing what the theory predicts

doi: 10.1158/0008-5472.Can-09-1947 32 GuertinDASabatiniDM

The LEADER trial for liraglutide and SUSTAIN-6 for semaglutide established cardiovascular benefit for that class

The dosing itself does not change, but the monitoring requirements are more stringent

Parkinsonism Relat Disord 83:1521 [DOI] [PubMed] [Google Scholar] Christine CW et al (2018) Vitamin B12 and homocysteine levels predict different outcomes in early Parkinsons disease

Medical Disorders People who have liver disorders often have difficulty storing vitamin B12, so it is quickly absorbed into the body rather than stored for later use