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An experimental component showed that administering a GLS1 inhibitor to a mouse model of RA reduced inflammatory arthritis symptoms, indicating a potential therapeutic pathway targeting metabolic processes [286]
Composite models showed 66- or 60-protein 5 MDa complexes comprising 12 Gid1:6 Gid2:6 Gid4:6 Gid5:12 Gid7:12 Gid8:6 Gid9 subunits, with or without 6 protomers of Gid12, respectively (Supplementary Fig

Youre creating a situation where your digestive system is being slowed through multiple pathways simultaneously, and the metabolic burden multiplies

Chee, W

doi: 10.1038/s41467-023-41346-y 56 WittigBMSabatRHolzlohnerPWitte-HandelEHeilmannKWitteKet al
