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K., Lysiuk, R., Antonyak, H., Noor, S., Akram, M., Smetanina, K., Piscopo, S., Upyr, T., & Peana, M

doi: 10.1016/J.JNUTBIO.2016.12.011 [DOI] [PubMed] [Google Scholar] 111.Zhou B, Yang Y, Pang X, Shi J, Jiang T, Zheng X

Arachidonic acid-derived eicosanoids have a pro-inflammatory effect, but eicosanoids made from omega-3 fatty acids have an anti-inflammatory effect

In addition, Dex can activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1)-mediated mitochondrial biogenesis pathway to enhance organ function

Overcoming these challenges will require advanced delivery platforms such as nanoparticles or hydrogels, personalized stratification tools such as lipidomic and ncRNA signatures, and rigorous pharmacokinetic validation in long-term OA models

These findings suggest that D 2 R and D 3 R loss affects extrastriatal areas more significantly than basal ganglia regions, implicating both motor and nonmotor regions in disease progression