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Evidence from in vitro studies confirms this conclusion, and it is clear that either AMG510 or MRTX849 results in a high proportion of KRAS secondary mutations, and 12 different secondary KRAS mutations are found

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ORCID: Affiliation: 5 PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil These authors contributed equally to this work

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