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Aggressive handling, like shaking the vial, can shear the peptide bonds, a process called denaturing

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[DOI] [PubMed] [Google Scholar] 36.Manconi M., Caddeo C., Sinico C., Valenti D., Mostallino M.C., Lampis S., Monduzzi M., Fadda A.M

A toxic dose has never been recorded