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We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion

The activation of Bax leads to its translocation to the mitochondria, disrupting the membranes permeability

K.PhamC.FoppenE.DenisR

Nitric oxide synthase regulates vascular tone, and tissue hypoxia during ischemia impacts both endothelial cells and smooth muscle cells, contributing to vascular dysfunction

Gastroenterology 117 : 11-16

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