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98:e17518

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The researchers observed that myeloma NCI - H929 cells were significantly sensitive to the chloroform fractions of TCF and ACF, and ferroptosis inhibitors eliminated the cytotoxicity of TCF and ACF extracts ( Andrographolide (AP), a diterpenoid lactone isolated from Andrographis paniculata, is the main component of this plant and exhibits a wide range of pharmacological effects

Gann, 70: 817-820

The activation of pyroptosis involves proteolytic cleavage of gasdermins by specific caspases, which liberates the pore-forming N-terminal fragment from the autoinhibitory C-terminal domain (74)