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10.1271/bbb.64.1203 Biosci

The liver clears toxins, metabolic byproducts, and medications via a two-phase system
Similarly, NOX4 has been shown to be overexpressed in various tumor types and implicated in cellular proliferation and survival [35]

Most often the effector is a member of the MAPK family

doi: 10.1126/science.290.5496.1571
If you want a deeper look at the mechanism, our guide to Liposomal Delivery explains how this approach supports absorption