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Patients may experience: Persistent fatigue and weakness Breathlessness on exertion Pallor or a slightly yellowish tinge to the skin Heart palpitations Neurological symptoms are of particular clinical concern, as nerve damage caused by prolonged B12 deficiency can be irreversible if not treated promptly

At the time of writing, six clinical trials involving treatment with Fragment 176-191 have taken place, involving doses ranging from 25 g 400 g/kg bodyweight (via I.V

Organ-specific protection mediated by cooperation between vascular and epithelial barriers

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Leng M, Zhao Y, Xiao H, Li C, Wang Z

This has been demonstrated with the 5-HT 4 agonist, prucalopride, which modified responses of T2helper cells and shortened post-operative ileus (Matteoli et al., 2013