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Cells isolation from freshly donated peripheral blood was done using Ficoll-paque plus density gradient centrifugation (Amersham Biosciences, Little Chalfont, UK)

Acknowledgments We thank the Servier Medical Art for the use of Powerpoint images from their images bank

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273 In Tca8113 cells, apigenin restrains the p-MEKK1, p-ERK1/2, thus prevent the proliferation, invasion, and migration of tumor cells

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