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Lens opacification, or cataracts, are the leading cause of vision impairment and blindness worldwide ( Cortical cataract, the second most prevalent form of cataract, occurs earlier than age-related nuclear (ARN) cataract ( Figure 1A ) ( Figure 1B ) occurs when the intrinsic repair and protection mechanisms that exist to mitigate the effects of oxidative stress slowly deteriorate or become ineffective ( Figure 1C ) are characterised by dysplasia of the equatorial epithelial cells ( Figure 1 (B) Nuclear cataract, from Ophthalmic Atlas Images by EyeRounds.org

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Recent studies indicate that the one-carbon metabolism is a significant source of NADPH in the mitochondria and, to a lesser extent, in the cytoplasm