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10.1111/acel.12947 333 ZhouM.ShaoJ.WuC

There are 2 varieties of NF1 that are principally characterized by the presence of deep neurofibromas: spinal neurofibromatosis, in which deep bilateral neurofibromas are present in all spinal roots with or without other manifestations of NF1,55 and orbital or cranio-orbitotemporal neurofibromatosis, in which the neurofibroma occupies the entire orbit, invades the orbital muscles, and is associated with exophthalmos, ocular assymetry, temporal deformity, sphenoid dysplasia, and temporal lobe herniation.56 This latter form of NF1 is very disfiguring and very difficult to correct

This process is called enterohepatic circulation

We verified the presence of hepatocytes by the cytosolic expression of GS and CPS1 along with nuclear expression of the hepatic transcription factor HNF4, which was located on the outer surface of the organoids (Fig

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