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Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]

Actin exists in two forms: free monomers (G-actin) and the polymerized filaments (F-actin) that give cells their structural scaffolding

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Trigger point injections (TPI) are a standard method of pain management designed to target and relieve tight, painful muscle knots known as trigger points

10.1093/sleep/zsab072.137 18 KorenicS