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Mol Pharmacol 53:355369 Lee ML, Martinez-Lozada Z, Krizman EN, Robinson MB (2017) Brain endothelial cells induce astrocytic expression of the glutamate transporter GLT-1 by a Notch-dependent mechanism

Several studies have shown close links between the antioxidant and glyoxalase systems in plants, suggesting a direct influence of the glyoxalase system on ROS detoxification (Yadav et al., 2005a

Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation

Some patients also worry that recurring symptoms reflect ongoing exposure or reinfection

While short-term use may cause only transient effects, prolonged supraphysiological IGF-1 receptor activation could potentially cause unwanted tissue growth including cardiac hypertrophy, which at extreme levels could impair cardiac function, and growth of other organs