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Description

Some senolytics, such as FOXO4-DRI, require peptide-based delivery, which is complex and may limit clinical application.58 Blood-brain barrier penetration is another challenge, making it difficult for senolytics to target neurodegenerative diseases effectively.121 Long-Term Consequences and Need for Repeated Treatment: The long-term effects of senolytic therapy remain unclear, as eliminating senescent cells could disrupt tissue homeostasis

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In BALB/c mice, i.p

Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N -hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), a potent cognitive-enhancing molecule that proved to be very stable, capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, slowly cleared from the blood compartment, and sufficiently BBB-permeable