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However, when mutant FUS, TDP-43, and ATXN2 aggregate within stress granules, they form insoluble aggregates, impacting appropriate transcription [12, 219]
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Single doses in the range of 3 to 6 grams were less likely to provoke symptoms, but larger doses, especially when taken in a single serving, often resulted in diarrhea and other gastrointestinal symptoms
