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Orally or even by injection, most short peptides face a gauntlet: peptidases in blood and tissue that chop them within minutes, poor membrane permeability that keeps them out of cells, and for any DNA-level mechanism the further barrier of reaching the nucleus intact

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 30(19), pp.23142326

Loren Pickart, and it can naturally be found in human saliva, plasma, and urine.12 (The GHK in skin care products is synthetic.) Experts originally believed GHK was a liver cell growth factor, but as research advanced, they learned that the peptide could alter far more cells than just those in the liver

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It decreases the sensitivity of neuron receptors to the excitatory actions of glutamate