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CYP1A2 is the primary enzyme responsible for metabolizing caffeine in the liver, although other enzymes also contribute to a lesser extent

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Additionally, EGCG can modulate epigenetic machinery by inhibiting DNA methyltransferases and histone deacetylases (HDACs), reactivating silenced tumorsuppressor genes

MOTS-c A mitochondrial-derived peptide often discussed for supporting metabolic flexibility and cellular energy production

Conclusion In conclusion, this review demonstrates that lactate and lactylation modifications, due to their involvement in critical brain metabolic pathways and their regulation of various gene transcription and protein functions, play a crucial regulatory role in the context of brain diseases

Second, more PK studies are needed to understand the effect of STS on cisplatin kinetics, including measurement of unbound cisplatin and carboplatin
