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In recent years, the Nrf2/HO-1 pathway has emerged as a pivotal player in the progression or prevention of ferroptosis across a spectrum of diseases (such as gastric cancer, neurological diseases, osteoporotic fractures and liver cancer) (64-67)

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Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop

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