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132 In obesity-driven postmenopausal cancer mouse models, TRF was shown to delay the onset of tumors and reduce lung metastasis

4 In elderly and insomniacs proximal skin warming markedly slowed the response speed in vigilance tasks

While mice lacking adipose HSL can achieve near normal rates of TAG hydrolysis, these animals display severely blunted DAG lipase activity, and as a result, DAG accumulates in adipose tissues (44)

This is the central paradox: the same mechanism that benefits the brain may pose systemic risk in individuals with latent malignancies or high cancer susceptibility